Solid support with a grafted chain

摘要

Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.

主权项

1. An article comprising a modified grafted support of Formula (V)
SS—(CO)—NH—C(R1)2—(CH2)p—(CO)-Q-Y1-Q-(CO)—CR2U4—CH2—U3  (V) wherein
SS comprises a solid support in the form of a membrane, foam, film, sheet, or coating on a substrate;p is an integer equal to 0 or 1;each R1 is each independently selected from alkyl, heteroalkyl, aryl, or aralkyl;Y1 is a first linking group comprising an alkylene, heteroalkylene, arylene, or combination thereof;each Q is independently a divalent group selected from oxy, thio, or —NR3— where R3 is hydrogen, alkyl, heteroalkyl, aryl, or aralkyl;each R2 is independently hydrogen or an alkyl;U3 comprises at least one divalent monomeric unit of formula CR2(Y2L-T)-CH2—;Y2 is a second linking group selected from a single bond or a divalent group comprising an alkylene, heteroalkylene, arylene, or combination thereof;U3 includes at least one divalent monomeric unit of formula —CR2(Y2L-T)-CH2—;U4 is hydrogen or comprises at least one divalent monomeric unit of formula —CR2(Y2L-T)-CH2—;L is an attachment group formed by reacting group Z1 with a modifying group A of a modifying agent A-T;Z1 is a functional group selected from (1) an acidic group or a salt thereof, (2) an amino group or a salt thereof, (3) a hydroxyl group, (4) an azlactone group or a precursor of the azlactone group, (5) a glycidyl group, or (6) a combination thereof; andT is a remainder of the modifying agent A-T and is equal to the modifying agent A-T minus the modifying group A.