| 主权项 |
1. A compound of general formula I wherein
substituent X can be selected independently from a group comprising BH, CH, BR1 and CR1, whereas concurrently at most four X can be CH or CR1 and whereas at least one group BR1 or CR1 is present;R1 in at least one substituent X is selected from a group comprising A-NHSO2NH2, A-SO2NH2 and A-O—SO2NH2, andR1 in other substituents X can be selected independently from a group comprising A-NHSO2NH2, A-SO2NH2, A-O—SO2NH2, C1-C8 alkyl, C2-C8 alkenyl, C6-C10 aryl, C2-C8 alkynyl, C4-C10 heteroaryl containing a heteroatom O, S or N, C1-C8 alkoxy, C1-C8 alkylhydroxy, C1-C8 alkylmercapto, OH, NH2, NH3+, C1-C8 alkylammonium, C1-C8 alkylamino, halogen;A is selected from a group comprising a single bond or bivalent linear C1-C10 hydrocarbon chain, wherein at least one carbon atom can optionally be replaced by heteroatoms selected from a group comprising N, S, O, or by C4-C10 heteroarylene, wherein the heteroatom is selected from O, N and S; Y is MR2, or Y is not present;
M is a metal of VIB or VIIIB group of periodic table;R2 is selected from a group comprisinga structure of general formula II wherein X is as defined above whereas concurrently at most three X can be CH or CR1; R1 is selected independently from a group comprising A-O—SO2NH2, A-SO2NH2, A-NHSO2NH2, C1-C8 alkyl, C2-C8 alkenyl, C6-C10 aryl, C2-C8 alkynyl, C4-C10 heteroaryl containing O, S or N as heteroatom, C1-C8 alkoxy, C1-C8 alkylhydroxy, C1-C8 alkylmercapto, OH, NH2, NH3+, C1-C8 alkylammonium, C1-C8 alkylamino, halogen,
and A is as described above,η5-bonded cyclopentadienyl, optionally substituted by 1 to 5 methyls, andη6-bonded phenyl ring, optionally bearing from 1 to 6 C1-C6 alkyl groups; Z is H or is not present; whereas from one to three Z are H only when Y is not present;
wherein alkyl denotes a linear or branched C1-C8 hydrocarbon moiety not comprising multiple bonds, which can optionally be substituted by one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2, SH; alkenyl denotes a linear or branched C2-C8 hydrocarbon chain, comprising at least one double bond, which can optionally be substituted by one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2, SH, SO3H; alkynyl denotes a linear or branched C2-C8 hydrocarbon chain, comprising at least one triple bond and optionally also at least one double bond, which can be optionally substituted by one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2, SH, SO3H; aryl denotes a C6-C10 aromatic carbocyclic group, comprising at least one aromatic ring or condensed aromatic rings, which can be optionally substituted by one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2, SH, SO3H; heteroaryl denotes a C4-C10 aromatic carbocyclic group, comprising at least one aromatic ring or condensed aromatic rings, in which at least one carbon atom is replaced by a heteroatom selected from a group comprising N, S, O, which can be optionally substituted by one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2, SH, SO3H; alkoxyl denotes a monovalent group derived from C1-C8 alcohol by the separation of a hydrogen atom from hydroxygroup; alkylamino is a group, created by a substitution of one or two hydrogen atoms of aminogroup by C1-C8 alkyl; alkylmercapto is a monovalent group derived from C1-C8 thiol by the cleavage of a hydrogen atom from SH group; halogen is fluorine, chlorine, bromine or iodine atom; bivalent linear C1-C10 hydrocarbon chain refers to a chain containing single bonds, optionally also double bonds, which binds oneself by terminal carbons;
and their pharmaceutically acceptable salts and solvates. |
