CDDO-Me amino acid conjugates and methods of use

摘要

2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid amino acid derivatives having antiinflammatory properties are provided. Pharmaceutical compositions and methods for preventing or treating inflammation or a disease or condition mediated by inflammation are described.

主权项

1. A compound of Formula I, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof: wherein R1 is an amino acid group or amino acid derivative; R2, R3 and R4 are each independently a hydrogen or a C1-C3 alkyl group; and X is —CH2— or —CH2—CH2—.