Systems and methods for treatment of allergies and other indications

摘要

The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising an H1 antihistamine and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

主权项

1. A composition for topical delivery to the skin of a subject, the composition comprising:
an ionic salt; a stabilization polymer comprising xanthan gum; propylene glycol; a polysorbate surfactant comprising polysorbate 20; an H1 antihistamine and/or a salt thereof; and a nitric oxide donor comprising L-arginine and/or L-arginine hydrochloride.