Method for diagnosing and treating NIS-expressing carcinomas and metastases

摘要

The present invention relates to a method for diagnosing and/or treating sodium-iodide symporter (NIS)-expressing primary carcinomas and metastases, preferably glandular carcinomas, in particular carcinomas of the thyroid, of the salivary gland, of the uterus and carcinomas of the breast, and to a pharmacological composition comprising substances which induce and/or increase the expression or function of the NIS symporter and, as a consequence, increase iodide uptake into the cells, and to corresponding uses. This can be used for an efficient tumor-specific radioiodide uptake in diagnosis and therapy of said carcinomas and metastases.

主权项

1. A method for diagnosing NIS gene-expressing carcinomas, metastases of carcinomas or both by stimulating or enhancing NIS gene expression in cells of the carcinomas or the metastases thereby increasing NIS-symporter function, comprising:
administering to a patient in need thereof at least one PPAR-γ ligand that is a thiazolidinedione, at least one ligand selected from the group consisting of RAR ligand and RXR ligand, and a radioactive affinity containing substance actively transported by the NIS symporter into cells of the carcinomas or the metastases; and stimulating or enhancing uptake of the radioactive affinity containing substance actively transported by the NIS symporter by induction of NIS gene expression in the cells.