发明名称 |
Compounds and methods for inhibiting phosphate transport |
摘要 |
Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I):;
including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. |
申请公布号 |
US9289429(B2) |
申请公布日期 |
2016.03.22 |
申请号 |
US201414329821 |
申请日期 |
2014.07.11 |
申请人 |
Ardelyx, Inc. |
发明人 |
Lewis Jason G.;Jacobs Jeffrey W.;Reich Nicholas;Leadbetter Michael R.;Bell Noah;Chang Han-Ting;Chen Tao;Navre Marc;Charmot Dominique;Carreras Christopher;Labonte Eric |
分类号 |
A61K31/5377;C07D239/42;C07D241/20;A61K31/497;A61K31/506;A61K31/59;A61K45/06 |
主分类号 |
A61K31/5377 |
代理机构 |
Cooley LLP |
代理人 |
Cooley LLP |
主权项 |
1. A pharmaceutical composition comprising:
a compound of structure (I): or a stereoisomer or pharmaceutically acceptable salt thereof,
wherein:
A is: X is substituted aryl or substituted heteroaryl;Y is halogen, optionally substituted alkylamino, optionally substituted alkoxy, optionally substituted thioalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, —O(optionally substituted cycloalkyl), —O(optionally substituted heterocyclyl) or —O(optionally substituted aryl);each R1 is, independently, hydrogen, C1-6alkyl or C1-6haloalkyl; andR2 is optionally substituted aryl or optionally substituted heteroaryl; and a pharmaceutically acceptable carrier, diluent, or excipient. |
地址 |
Fremont CA US |