Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (ARG)

摘要

The invention relates to the field of endothelial barrier dysfunction, particular, the invention relates to new methods for the treatment of endothelial barrier dysfunction, such as inflammatory edema by inhibiting Abl-related gene (ARG).

主权项

1. A method of treating an individual suffering from or at risk of suffering from inflammatory edema, the method comprising:
administering an inhibitor of Abl-related gene (ARG) function to the individual thereby treating said edema in the individual, wherein the inhibitor inhibits or alters the ARG gene, ARG mRNA, or ARG protein.