Potent anti APOB antisense compounds

摘要

The present invention relates to oligomer compounds (oligomers), which target APO-B100 mRNA in a cell, leading to reduced expression of APO-B100. Reduction of APO-B100 expression is beneficial for the treatment of certain medical disorders, such as diseases associated with apolipoproteinB activity, such as in non-limiting example, different types of HDL/LDL cholesterol imbalance; dyslipidemias, e.g., familial combined dyslipidemia (FCHL), acquired hyperlipidemia, hypercholesterolemia, statin-resistant hypercholesterolemia; coronary artery disease (CAD), coronary heart disease (CHD), atherosclerosis.

主权项

1. A single stranded oligomer of 12-18 nucleotides comprising a contiguous nucleotide sequence that is at least 90% identical SEQ ID NO:4 wherein the oligomer has six contiguous DNA nucleobases and at least two locked nucleic acids (LNA).