| 发明名称 | Yeast-based therapeutic for chronic hepatitis B infection | ||
| 摘要 | Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof. | ||
| 申请公布号 | US9290547(B2) | 申请公布日期 | 2016.03.22 |
| 申请号 | US201414494235 | 申请日期 | 2014.09.23 |
| 申请人 | GlobeImmune, Inc. | 发明人 | Apelian David;King Thomas H.;Guo Zhimin;Coeshott Claire |
| 分类号 | C12N7/00;C07K14/005;A61K39/29;A61K36/06;C07K14/02;A61K47/46;A61K36/12;A61K31/675;A61K39/00 | 主分类号 | C12N7/00 |
| 代理机构 | Sheridan Ross P.C. | 代理人 | Sheridan Ross P.C. ;Sebor Angela Dallas;Polster Phil |
| 主权项 | 1. A method of treating hepatitis B virus (HBV) infection or at least one symptom resulting from HBV infection in a subject, comprising administering to the subject that has been infected with HBV an immunotherapeutic composition comprising: a) a yeast vehicle comprising a fusion protein; b) the fusion protein comprising HBV antigens, wherein the HBV antigens consist of: i) an HBV X antigen having an amino acid sequence that is at least 90% identical to positions 1-60 of SEQ ID NO:130;ii) an HBV surface antigen having an amino acid sequence that is at least 90% identical to positions 63-461 of SEQ ID NO:130; andiii) an HBV core antigen having an amino acid sequence that is at least 90% identical to positions 462-643 of SEQ ID NO:130. | ||
| 地址 | Louisville CO US | ||