Method for protecting hydroxyl or amine or thiol functions, novel compounds with protected hydroxyl or amine or thiol groups, as well novel compounds for the implementation of this method

摘要

A novel method of simultaneously protecting two functions which are same or different, namely hydroxyl, amine, or thiol ones, particularly in sugars, polyalcohols, nucleosides, nucleotides, peptides, and nucleic acids during an organic synthesis, and to novel compounds for implementing this method, as well as to the method of obtaining these compounds. Method of simultaneously protecting two hydroxyl, amine, or thiol functions according to the invention by carrying out a protecting reaction between a compound having at least two free hydroxyl, amine, or thiol groups, and the disilane of formula 1,;
where R stands for Cl or Br, or I, or a substituent of formula 2,
;
where X1, X2, X3, X4 are the same or different.

主权项

1. A method of simultaneously protecting two hydroxyl, amine, or thiol functions, or one hydroxyl and one amine function, or one hydroxyl and one thiol function, or one thiol and one amine function, comprising protecting primary and secondary hydroxyl, amine, or thiol groups, wherein a compound containing at least two free hydroxyl, amine, or thiol groups, or at least one hydroxyl group and one amine group, or at least one hydroxyl group and one thiol group, or at least one amine group and one thiol group is made to react with a compound of general formula 1, where R stands for CI or Br or I, or a substituent of formula 2, where X1, X2, X3, X4 are the same or different and stand for N or CH, or C—R1 groups, where R1s are the same or different, and stand for:
a saturated alkyl containing 1 to 8 carbon atoms,an unsaturated alkyl containing 2 to 8 carbon atoms,an aryl;a substituted saturated alkyl containing 1 to 8 carbon atoms and an aryl substituent,a substituted unsaturated alkyl containing 2 to 8 carbon atoms and an aryl substituent;wherein, in each case, at least one X is different from N,in the environment of an aprotic solvent.