主权项 |
1. A tricyclic compound represented by: wherein: the ring B2 is optionally substituted by one or more fluorine atoms on any of the available carbon atoms; B2 is fused to ring D2 such that the two atoms shared by B2 and D2 are both carbon; X2 is +—W2—C(RD5RD6)—*; wherein the + and * indicate the attachment points of X2 as indicated in Formula II; Y is a bond; wherein the * and # indicate the attachment points of Y as indicated in Formula II; W2 is O; A is phenyl; RB1 and RB2 are independently selected from the group consisting of H, F, OH, CN, C1-2alkoxy or C1-3alkyl; wherein C1-3alkyl and C1-2alkoxy are optionally substituted by a group selected from OH, C1-2alkoxy, CN or one or more fluorine atoms; RA1 is selected, independently for each occurrence, from the group consisting of hydrogen, hydroxyl, cyano, halogen, C1-4alkyl or C1-3alkoxy; wherein or C1-3alkoxy may be optionally substituted by one or more fluorines; n is 0, 1, or 2; RA2 is selected from the group consisting of hydrogen, RiRjN—, heterocyclyl, C1-6alkyl, C3-6alkenyl, C3-6cycloalkyl, C1-6alkoxy; wherein said heterocyclyl may optionally be substituted by one or more groups Rg; and wherein if said heterocyclyl contains a —NH moiety, that nitrogen may optionally be substituted by one or more groups Rh; and wherein said C1-6alkyl, C3-6alkenyl, C3-6cycloalkyl and C1-6alkoxy may optionally be substituted by one or more groups RP; RD5 and RD6 are each independently selected from the group consisting of hydrogen, fluorine, hydroxyl, cyano, C1-2alkyl or C1-2alkoxy; wherein the C1-2alkyl and C1-2alkoxy may optionally be substituted by a substituent or substituents selected from the group consisting of: one or more fluorine atoms, cyano, hydroxyl or N(RaRb); Ra and Rb are independently selected, for each occurrence, from the group consisting of hydrogen and C1-3alkyl; wherein C1-3alkyl may optionally be substituted by one or more substituents selected from fluorine, cyano, oxo and hydroxyl; or Ra and Rb, together with the nitrogen to which they are attached, may form a 4-6 membered heterocyclic ring, which may have an additional heteroatom selected from O, S, or N; wherein the 4-6 membered heterocyclic ring may optionally be substituted by one or more substituents selected from the group consisting of fluorine, cyano, oxo or hydroxyl; Rg is independently selected for each occurrence from the group consisting of RP, hydrogen, oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, C1-6alkyl-S(O)w—, (wherein w is 0, 1 or 2), C1-6alkylcarbonyl-N(Ra)— and C1-6alkoxycarbonyl-N(Ra)—; wherein C1-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C1-6 alkoxy may be optionally substituted by one or more substituents selected from RP; Rh is independently selected for each occurrence from the group consisting of hydrogen, C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-6cycloalkyl, C1-6alkyl-S(O)2—, C1-6alkoxycarbonyl-, RiRjN-carbonyl- and RiRjN—SO2—; wherein C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-6cycloalkyl may optionally be substituted by one or more substituents selected from RP; Ri and Rj are selected independently for each occurrence from the group consisting of hydrogen, C1-4alkyl C3-6cycloalkyl, heterocyclyl and heterocyclylcarbonyl; wherein C1-4alkyl and C3-6cycloalkyl may be optionally substituted by one or more substituents selected from fluorine, hydroxyl, cyano, RaRbN—, RaRbN-carbonyl- and C1-3alkoxy and wherein heterocyclyl and heterocyclylcarbonyl may be optionally substituted by one or more substituents selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C1-6alkoxy, halo-C1-6-alkyl, hydroxyl-C1-6-alkyl, RaRbN—C1-6alkyl- and C1-6-alkoxy-C1-6-alkyl group; and wherein if said heterocyclyl or heterocyclylcarbonyl contains a —NH moiety that nitrogen may optionally be substituted by one or more groups C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-6cycloalkyl, C1-6alkyl-S(O)2— and C1-6-alkylcarbonyl; or Ri and Rj taken together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring, which may have an additional heteroatom selected from O, S, or N; wherein the 4-7 membered heterocyclic ring may be optionally substituted on carbon by one or more substituents selected from the group consisting of fluorine, hydroxyl, oxo, cyano, C1-6alkyl, C1-6alkoxy, RaRbN—, RaRbN—SO2— and RaRbN-carbonyl-; wherein said C1-6alkyl or C1-6alkoxy may optionally be substituted by fluorine, hydroxyl or cyano; and wherein the 4-7 membered heterocyclic ring may be optionally substituted on nitrogen by one or more substituents selected from the group consisting of C1-6alkyl and RaRbN-carbonyl-; and wherein said C1-6alkyl may be optionally substituted by one or more substituents selected from the group consisting of fluorine, hydroxyl, cyano; RP is independently selected, for each occurrence, from the group consisting of halogen, hydroxyl, cyano, C1-6alkoxy, RiRjN—, RiRjN-carbonyl-, RiRjN—SO2— and RiRjN-carbonyl-N(Ra)—; and pharmaceutically acceptable salts, and stereoisomers thereof. |