Pyridazinone compounds and their use as DAAO inhibitors

摘要

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.;

主权项

1. A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is chosen from a hydrogen or fluorine atom or a trifluoromethyl group: R2 represents a group —X—Y—R3; X and Y each independently are chosen from a bond, an oxygen atom, or a group —C(O), —S(O)n, —C(O)NR4, —S(O)2NR4, —NR4,or —CR4R5—, with the proviso that X and Y cannot both simultaneously represent a bond, and if X and Y are both not a bond, then at least one of X and Y represents —CR4R5—;
n is chosen from 0, 1 or 2; each R4 independently is chosen from a hydrogen atom or a C1-C6, alkyl or C1-C6, haloalkyl group; each R5 independently is chosen from a hydrogen atom, a C1-C6 alkyl or C1-C6 haloalkyl group or ═CH—; R3 is chosen from a 3- to 10-membered saturated or unsaturated carbocyclic or heterocyclic ring system, wherein the ring system is unsubstituted or substituted by at least one substituent chosen from halogen, hydroxyl, cyano, oxo, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 alkylsulphinyl, C1-C6 alkylsulphonyl, C1-C6 alkylcarbonyl, C1-C6 alkylcarbonyloxy, C1-C6 alkoxycarbonyl, amino (NH2), —CON(R6)2, C1-C6 alkylamino, di-(C1-C6 alkyl)amino, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy, C3-C6 cycloalkylmethyl, —[O]p—(CH2)q—O—R7 or a 4 to 6-membered saturated or unsaturated heterocyclic ring, which is unsubstituted or substituted with at least one substituent chosen from C1-C4 alkyl or C1-C4 alkoxy; each R6 independently is chosen from a hydrogen atom or a C1-C6 alkyl group; p is chosen from 0 or 1; q is chosen from 1, 2, 3 or 4; and R7 is chosen from a C1-C6 alkyl group.