发明名称 |
1-(Arylmethyl)quinazoline-2,4(1<i>H</i>,3<i>H</i>)-diones as PARP inhibitors and the use thereof |
摘要 |
Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones thereof, represented by the Formula (I) wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity.; |
申请公布号 |
US9290460(B2) |
申请公布日期 |
2016.03.22 |
申请号 |
US201214006722 |
申请日期 |
2012.03.31 |
申请人 |
IMPACT THERAPEUTICS, INC. |
发明人 |
Cai Sui Xiong;Tian Ye Edward;Hu Xiuhua |
分类号 |
C07D403/12;A61K31/517;C07D239/96;C07D401/06;A61K45/06;C07D401/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D471/04;C07D487/04 |
主分类号 |
C07D403/12 |
代理机构 |
Sterne, Kessler, Goldstein and Fox P.L.L.C |
代理人 |
Sterne, Kessler, Goldstein and Fox P.L.L.C |
主权项 |
1. A compound 5-fluoro-1-(4-fluoro-3-(pyrimidin-2-yl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione, or a pharmaceutically acceptable salt thereof. |
地址 |
CN |