MOUSE MODEL OF INFLAMMATION WITH IL33 N-TERMINAL DOMAIN DELETION

摘要

FIELD: medicine.SUBSTANCE: invention refers to biotechnology and gene engineering. What is described is a mouse having an incomplete N-terminal domain in IL-33 gene. The mouse is used as a model in vivo of inflammatory diseases for methods for selecting anti-inflammatory compounds and methods for assessing and optimising pharmacological properties of a certain anti-inflammatory compound.EFFECT: invention can be used in pharmacology and medicine.12 cl, 8 dwg, 3 ex