发明名称 |
AGENT REPRESENTING GLYCYRRHIZIC ACID AMIDE WITH 5-AMINOURACIL SHOWING ANTIVIRAL ACTIVITY ON A/H1N1 INFLUENZA VIRUS |
摘要 |
FIELD: medicine.SUBSTANCE: invention refers to an agent representing glycyrrhizic acid amide with 5-aminouracil of formula (1)showing antiviral activity on A/H1N1 influenza virus. The presented agent (GA amide (1)) is 5 times less toxic for MDCK cells (CTD300 mcg/ml) than rimantadin, a known antiviral preparation (CTD60 mcg/ml), and possesses high antiviral activity; 50% effective concentration (EC) of GA amide (1) is 0.2 mcg/ml, and in reference preparations: GA - 174 mcg/ml, rimantadin - 12 mcg/ml. GA amide (1) has a higher selectivity index (SI 1500) as compared to the reference preparations and 500 times as high as that of GA (SI 3.0) and 300 times as much as that of rimantadin (SI 5.0).EFFECT: higher selectivity index of amide.1 tbl, 3 ex |
申请公布号 |
RU2568849(C9) |
申请公布日期 |
2016.03.20 |
申请号 |
RU20140144876 |
申请日期 |
2014.11.06 |
申请人 |
FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE NAUKI INSTITUT ORGANICHESKOJ KHIMII UFIMSKOGO NAUCHNOGO TSENTRA ROSSIJSKOJ AKADEMII NAUK (IOKH UNTS RAN) |
发明人 |
BALTINA LIDIJA ASHRAFOVNA;BALTINA LIJA ALEKSANDROVNA;ZARUBAEV VLADIMIR VIKTOROVICH;KISELEV OLEG IVANOVICH;JUNUSOV MARAT SABIROVICH |
分类号 |
A61K31/7068;A61K31/506;A61P31/16 |
主分类号 |
A61K31/7068 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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