A PREPARATION METHOD OF ECTEINASCIDIN-743 INTERMEDIATE -743

摘要

The invention relates to a method for preparing an intermediate of ecteinascidin-743 and particularly relates to a method for preparing an intermediate which is used for synthesizing ecteinascidin-743 and is represented by the formula I as shown in the description. The method comprises the following steps of carrying out protecting group conversion on a compound represented by the formula X as shown in the description in the presence of a chiral phase transfer catalyst to obtain a chiral intermediate represented by the formula V as shown in the description, carrying out esterification reaction on the intermediate V to obtain an intermediate represented by the formula IV as shown in the description and then carrying out intramolecular cyclization reaction and removing the protecting groups to obtain the intermediate which is used for synthesizing ecteinascidin-743 and is represented by the formula I. The method has the advantages of mild reaction conditions, simplicity in operation, low synthesis cost and the like and is suitable for mass production.