发明名称 |
SUBSTITUTED PYRROLIDINE COMPOUNDS |
摘要 |
The present disclosure provides substituted pyrrolidine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer. |
申请公布号 |
WO2016040504(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
WO2015US49219 |
申请日期 |
2015.09.09 |
申请人 |
EPIZYME, INC. |
发明人 |
FOLEY, MEGAN ALENE CLOONAN;KUNTZ, KEVIN WAYNE;MITCHELL, LORNA HELEN;MUNCHHOF, MICHAEL JOHN;HARVEY, DARREN MARTIN |
分类号 |
A01N43/80 |
主分类号 |
A01N43/80 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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