发明名称 NEMATICIDAL N-(PHENYLCYCLOALKYL)CARBOXAMIDES AND N-(PHENYLCYCLOALKYL)THIOCARBOXAMIDES
摘要 The present invention relates to the use of N-(Phenylcycloalkyl)carboxamides and N-(Phenylcycloalkyl)thiocarboxamides for the control of nematodes in agriculture and as anthelmintic agents against endoparasites in animals and humans, compositions containing such compounds and methods for the control of nematodes and helminths and furthermore to novel N-(Phenylcycloalkyl)carboxamides and N-(Phenylcycloalkyl)thiocarboxamides, processes and intermediate compounds for their preparation, their use as nematicides, compositions containing such compounds and methods for the control of nematodes.
申请公布号 US2016075653(A1) 申请公布日期 2016.03.17
申请号 US201414787530 申请日期 2014.04.28
申请人 BAYER CROPSCIENCE AKTIENGESELLSCHAFT 发明人 DECOR Anne;GREUL Joerg;HEILMANN Eike Kevin;SCHWARZ Hans-Georg;GESING Ernst Rudolf;FRACKENPOHL Jens;ELBE Hans-Ludwig;WIESE Welf Burkhard;PORTZ Daniela;ILG Kerstin;MALSAM Olga;LOESEL Peter;LUEMMEN Peter;GOERGENS Ulrich;COQUERON Pierre-Yves;MARTELLETTI Arianna;DESBORDES Philippe;GARY Stephanie;CHRISTIAN Isabelle;WELZ Claudia
分类号 C07D213/81;C07D213/82;C07C233/66;C07D231/14 主分类号 C07D213/81
代理机构 代理人
主权项 1. A compound of formula (I)wherein A represents phenyl of formula Aawherein * indicates the bond which connects Aa to the C=T moiety of the compound of formula (I), Y1 represents halogen, nitro, SH, SF5, CHO, OCHO, NHCHO, cyano, C1-C8-alkyl, C1-C8-halogenoalkyl having 1 to 5 halogen atoms, C2-C8-alkenyl, C2-C8-alkynyl, C3-C6-cycloalkyl, C3-C6-halogenocycloalkyl having 1 to 9 halogen atoms, C1-C8-alkylsulfanyl, —C1-C8-halogenoalkylsulfanyl having 1 to 5 halogen atoms, C1-C8-alkoxy, C1-C8-halogenoalkoxy having 1 to 5 halogen atoms, C1-C8-alkoxy-C1-C8-alkyl, C2-C8-alkenyloxy-C1-C8-alkyl, C3-C8-alkynyloxy-C1-C8-alkyl, C2-C8-alkenyloxy, C3-C8-alkynyloxy, C1-C8-alkoxycarbonyl, C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, C1-C8-alkylcarbonyloxy, C1-C8-halogenoalkylcarbonyloxy having 1 to 5 halogen atoms, C1-C8-alkylsulfinyl, C1-C8-halogenoalkylsulfinyl having 1 to 5 halogen atoms, C1-C8-alkylsulfonyl, C1-C8-halogenoalkylsulfonyl having 1 to 5 halogen atoms, C1-C8-alkylsulfonamide, substituted or unsubstituted tri-(C1-C8)-alkylsilyl, substituted or unsubstituted aryl and substituted or unsubstituted aryloxy; Y2, Y3, Y4 and Y5 independently from each other represent hydrogen or Y1; or A represents a carbo-linked heterocyclyl group optionally substituted by 1 to five groups R, wherein R independently from each other R represents hydrogen, halogen, nitro, cyano, hydroxy, amino, sulfanyl, pentafluoro-λ6-sulfanyl, substituted or unsubstituted (C1-C8-alkoxyimino)-C1-C8-alkyl, substituted or unsubstituted (benzyloxyimino)-C1-C8-alkyl, substituted or unsubstituted C1-C8-alkyl, C1-C8-halogenoalkyl having 1 to 5 halogen atoms, substituted or unsubstituted C2-C8-alkenyl, C2-C8-halogenoalkenyl having 1 to 5 halogen atoms, substituted or unsubstituted C2-C8-alkynyl, C2-C8-halogenoalkynyl having 1 to 5 halogen atoms, substituted or unsubstituted C1-C8-alkoxy, C1-C8-halogenoalkoxy having 1 to 5 halogen atoms, substituted or unsubstituted C1-C8-alkylsulfanyl, C1-C8-halogenoalkylsulfanyl having 1 to 5 halogen atoms, substituted or unsubstituted C1-C8-alkylsulfinyl, C1-C8-halogenoalkylsulfinyl having 1 to 5 halogen atoms, substituted or unsubstituted C1-C8-alkylsulfonyl, C1-C8-halogenoalkylsulfonyl having 1 to 5 halogen atoms, substituted or unsubstituted C1-C8-alkylamino, substituted or unsubstituted di-C1-C8-alkylamino, substituted or unsubstituted C2-C8-alkenyloxy, substituted or unsubstituted C3-C8-alkynyloxy, substituted or unsubstituted C3-C7-cycloalkyl, C3-C7-halogenocycloalkyl having 1 to 5 halogen atoms, substituted or unsubstituted tri-(C1-C8-alkyl)-silyl, substituted or unsubstituted C1-C8-alkylcarbonyl, C1-C8-halogenoalkylcarbonyl having 1 to 5 halogen atoms, substituted or unsubstituted C1-C8-alkoxycarbonyl, C1-C8-halogenoalkoxycarbonyl having 1 to 5 halogen atoms, substituted or unsubstituted C1-C8-alkylcarbamoyl, substituted or unsubstituted di-(C1-C8)-alkylcarbamoyl, phenoxy, phenylsulfanyl, phenylamino, benzyloxy, benzylsulfanyl, or benzylamino, T represents oxygen or sulphur, B represents a 3-, 4-, 5-, 6- or 7-membered non-aromatic carbocycle optionally substituted by substituents selected from the group consisting of one to four C1-C8-alkyl groups and one to four halogen atoms, n represents 0, 1, 2, 3, 4 or 5, X independently from each other X represents halogen, nitro, cyano, isonitrile, hydroxy, amino, sulfanyl, pentafluoro-λ6-sulfanyl, formyl, formyloxy, formylamino, substituted or unsubstituted (hydroxyimino)-C1-C8-alkyl, substituted or unsubstituted (C1-C8-alkoxyimino)-C1-C8-alkyl, substituted or unsubstituted (C2-C8-alkenyloxyimino)-C1-C8-alkyl, substituted or unsubstituted (C3-C8-alkynyloxyimino)-C1-C8-alkyl, substituted or unsubstituted (benzyloxyimino)-C1-C8-alkyl, carboxy, carbamoyl, thiocarbamoyl, N-hydroxycarbamoyl, carbamate, substituted or unsubstituted C1-C8-alkyl, C1-C8-halogenoalkyl having 1 to 9 halogen atoms, substituted or unsubstituted C2-C8-alkenyl, C2-C8-halogenoalkenyl having 1 to 9 halogen atoms, substituted or unsubstituted C2-C8-alkynyl, C2-C8-halogenoalkynyl having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkoxy, C1-C8-halogenoalkoxy having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkylsulfanyl, C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkylsulfinyl, C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkylsulfonyl, C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkylamino, substituted or unsubstituted di-(C1-C8-alkyl)-amino, substituted or unsubstituted C2-C8-alkenyloxy, C2-C8-halogenoalkenyloxy having 1 to 9 halogen atoms, substituted or unsubstituted C3-C8-alkynyloxy, C3-C8-halogenoalkynyloxy having 1 to 9 halogen atoms, substituted or unsubstituted C3-C7-cycloalkyl, C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms, substituted or unsubstituted C3-C7-cycloalkyloxy, substituted or unsubstituted C4-C7-cycloalkenyl, C4-C7-halogenocycloalkenyl having 1 to 9 halogen atoms, substituted or unsubstituted (C3-C7-cycloalkyl)-C1-C8-alkyl, substituted or unsubstituted (C3-C7-cycloalkyl)-C2-C8-alkenyl, substituted or unsubstituted (C3-C7-cycloalkyl)-C2-C8-alkynyl, substituted or unsubstituted tri-(C1-C8-alkyl)-silyl, substituted or unsubstituted tri-(C1-C8-alkyl)-silyl-C1-C8-alkyl, substituted or unsubstituted C1-C8-alkylcarbonyl, C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkylcarbonyloxy, C1-C8-halogenoalkylcarbonyloxy having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkylcarbonylamino, C1-C8-halogenoalkylcarbonylamino having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkoxycarbonyl, C1-C8-halogenoalkoxycarbonyl having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkyloxycarbonyloxy, C1-C8-halogenoalkoxycarbonyloxy having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkylcarbamoyl, substituted or unsubstituted di-C1-C8-alkylcarbamoyl, substituted or unsubstituted C1-C8-alkylaminocarbonyloxy, substituted or unsubstituted di-C1-C8-alkylaminocarbonyloxy, substituted or unsubstituted N—(C1-C8-alkyl)-hydroxycarbamoyl, substituted or unsubstituted C1-C8-alkoxycarbamoyl, substituted or unsubstituted N—(C1-C8-alkyl)-C1-C8-alkoxycarbamoyl, aryl optionally substituted by 1 to 6 groups Q which can be the same or different, aryl-C1-C8-alkyl optionally substituted by 1 to 6 groups Q which can be the same or different, aryl-C2-C8-alkenyl optionally substituted by 1 to 6 groups Q which can be the same or different, aryl-C2-C8-alkynyl optionally substituted by 1 to 6 groups Q which can be the same or different, aryloxy optionally substituted by 1 to 6 groups Q which can be the same or different, arylsulfanyl optionally substituted by 1 to 6 groups Q which can be the same or different, arylamino optionally substituted by 1 to 6 groups Q which can be the same or different, aryl-C1-C8-alkyloxy optionally substituted by 1 to 6 groups Q which can be the same or different, aryl-C1-C8-alkylsulfanyl optionally substituted by 1 to 6 groups Q which can be the same or different, aryl-C1-C8-alkylamino optionally substituted by 1 to 6 groups Q which can be the same or different, pyridinyl which can be substituted by 1 to 4 groups Q, pyridinyloxy which is optionally substituted by 1 to 4 groups Q, or two substituents X together with the carbon atoms to which they are attached form a 5- or 6-membered, saturated carbocycle or saturated heterocycle, which is optionally substituted by 1 to 4 groups Q which can be the same or different, Z1 and Z2 independently represent hydrogen, halogen, cyano, substituted or unsubstituted C1-C8-alkyl, C1-C8-halogenoalkyl having 1 to 5 halogen atoms, substituted or unsubstituted C1-C8-alkoxy, substituted or unsubstituted C1-C8-alkylsulfanyl, or substituted or unsubstituted C1-C8-alkoxycarbonyl, Z3 represents hydrogen, cyano, C1-C8-alkoxy, unsubstituted C3-C7-cycloalkyl or C3-C7-cycloalkyl substituted by 1 to 10 substituents that can be the same or different, selected from the list consisting of halogen, cyano, C1-C8-alkyl, C1-C8-halogenoalkyl comprising 1 to 9 halogen atoms, C1-C8-alkoxy, C1-C8-halogenoalkoxy comprising 1 to 9 halogen atoms, C1-C8-alkoxycarbonyl, C1-C8-halogenoalkoxycarbonyl comprising 1 to 9 halogen atoms, C1-C8-alkylaminocarbonyl and di-(C1-C8-alkyl)-amino, Q represents halogen, cyano, nitro, substituted or unsubstituted C1-C8-alkyl, C1-C8-halogenoalkyl having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkoxy, C1-C8-halogenoalkoxy having 1 to 9 halogen atoms, substituted or unsubstituted C1-C8-alkylsulfanyl, C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms, substituted or unsubstituted tri-(C1-C8-alkyl)-silyl, substituted or unsubstituted tri-(C1-C8-alkyl)-silyl-C1-C8-alkyl, substituted or unsubstituted C1-C8-alkoxyimino-C1-C8-alkyl, substituted or unsubstituted (benzyloxyimino)-C1-C8-alkyl, And/or an N-oxide, metallic complex, metalloidic complex and/or an optically active isomer of a compound of formula (I), capable of being used for controlling nematodes.
地址 Monheim am Rhein DE