NUCLEOTIDE PHOSPHATE DISSIPATION AS A TREATMENT FOR VASCULAR DISORDERS

摘要

The present invention provides a method of treating or preventing immunoinflammatory, vascular, thrombotic or ischemic disorders in a subject, the method comprises administering to the subject an agent which dissipates nucleotide phosphates or generates a product which stimulates adenosine receptors. The present invention also provides a method of treating or preventing immunoinflammatory, thrombotic or ischemic disorders in a subject by inhibiting leukocyte infiltration into a site which comprises administering to the subject an effective amount a described agent. Agents described for use in the methods of the invention include CD73, a fragment a mutant, or a modified form thereof.

主权项

1. A method of treating or preventing a vascular, thrombotic, ischemic, or immunoinflammatory disorder in a subject, the method comprising administering to the subject a composition comprising an effective amount of one or more agents which dissipate nucleotide monophosphate; with the proviso that when said composition comprises only one agent that dissipates nucleotide monophosphate, and said only one agent is soluble CD73, said disorder is not acute myocardial infarction or renal ischemia.