发明名称 |
Systems, Devices And Methods For In Situ Calibration Of Implantable Sensors |
摘要 |
Systems, methods, and devices are disclosed for monitoring or quantifying of various analyte levels in a biological fluid using one or more implantable sensors by providing in situ calibration and/or cleaning of such sensors when implanted in a patient. The systems and devices can continuously or serially measure analytes within a biological fluid in vivo (e.g., without extracting the biological fluid from the patient) and can be periodically calibrated and/or cleaned without using finger sticks or other calibration techniques. For example, the invention can facilitate continuous monitoring of glucose concentrations in subcutaneous interstitial fluid for several hours to a few days. In certain embodiments, the invention can employ two reservoirs, one containing and a known concentration of an analyte and the other containing a diluent, and a mixer for mixing analyte from the first reservoir diluent from the second reservoir to obtain a calibration fluid of a desired concentration. |
申请公布号 |
US2016073940(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
US201514832743 |
申请日期 |
2015.08.21 |
申请人 |
Winkelman James |
发明人 |
Winkelman James |
分类号 |
A61B5/1495;A61B5/1459;A61B5/1473;A61B5/145;A61B5/00 |
主分类号 |
A61B5/1495 |
代理机构 |
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代理人 |
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主权项 |
1. A system for monitoring the concentration of an analyte, comprising:
a sensor configured to be implanted at an implant site in a patient's skin, said sensor sensing an analyte present in a biological fluid at the implant site; a first reservoir configured to contain a calibration fluid having a first known concentration of said analyte; at least a second reservoir configured to contain a diluent for the calibration fluid; a mixer configured to mix a quantity of fluid from each of said reservoirs to obtain a calibration fluid of a desired concentration; and a conduit for delivering said calibration fluid from the reservoir to the implant site. |
地址 |
Chestnut Hill MA US |