PROGNOSTIC AND PREDICTIVE BREAST CANCER SIGNATURE

摘要

Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating a specified set of genes. Specifically, methods may comprise calculating a prognosis score based on a particular algorithm. Also disclosed are compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more upstream activators and/or downstream effectors of TET1.

主权项

1. A method for calculating a prognosis score of a breast cancer patient, comprising:
a) measuring the level of expression or activity in a breast cancer sample of at least four of the following seven biomarkers: RKIP, MMP1, OPN, HMGA2, CXCR4, let-7, and BACH1; b) comparing the level of expression or activity of each biomarker measured in a) to a reference expression level or activity; c) calculating a prognosis score, using a computer algorithm, wherein the prognosis score is based on comparisons in b).