| 发明名称 |
DIFFERNTIATION METHOD FOR PRODUCTION OF GLIAL CELL POPULATION |
| 摘要 |
The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in relatively pure cultures for long periods of time. The present invention also provides methods for further differentiating these oligodendrocyte progenitor cells into various glial cells. |
| 申请公布号 |
US2016075994(A1) |
申请公布日期 |
2016.03.17 |
| 申请号 |
US201514949578 |
申请日期 |
2015.11.23 |
| 申请人 |
Case Western Reserve University |
发明人 |
Tesar Paul J.;Miller Robert H.;Najm Fadi J. |
| 分类号 |
C12N5/079;A61K35/30 |
主分类号 |
C12N5/079 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for generating mammalian neuroectoderm comprising: providing pluripotent cells; and inducing development of the pluripotent cells into neuroectoderm by culturing the pluripotent cells in the presence of one or more inhibitors of an activin-nodal pathway and one or more inhibitors of a bone morphogenetic protein pathway. |
| 地址 |
Cleveland OH US |
