| 发明名称 |
METHODS OF TREATING SPINAL DISORDERS USING AUTOLOGOUS PROTEIN SOLUTIONS |
| 摘要 |
Methods for treating a spinal disorder, such as spinal pain or spinal inflammation, using a blood-derived composition having two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII. Compositions may also contain white blood cells and platelets. |
| 申请公布号 |
US2016074479(A1) |
申请公布日期 |
2016.03.17 |
| 申请号 |
US201514830977 |
申请日期 |
2015.08.20 |
| 申请人 |
Serbousek Jon C.;O'Shaughnessey Krista;Higgins Joel C.;Woodell-May Jennifer E.;Leach Michael D. |
发明人 |
Serbousek Jon C.;O'Shaughnessey Krista;Higgins Joel C.;Woodell-May Jennifer E.;Leach Michael D. |
| 分类号 |
A61K38/20;A61K38/18;A61K38/17 |
主分类号 |
A61K38/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a spinal structure disorder in a mammalian subject, comprising administering to a spinal structure a blood-derived composition comprising at least two proteins selected form interleukin-1 receptor antagonist (IL-1ra), soluble tumor necrosis factor receptor I (sTNF-RI), soluble tumor necrosis factor receptor II (sTNF-RII), insulin-like growth factor 1 (IGF-I), epidermal growth factor (EGF), hepatocyte growth factor (HGF), platelet-derived growth factor AB (PDGF-AB), platelet-derived growth factor BB (PDGF-BB), vascular endothelial growth factor (VEGF), transforming growth factor β1 (TGF-β1), and soluble interleukin-1 receptor II (sIL-1RII), wherein the concentration of each protein in the composition is greater than the concentration of the protein in normal blood. |
| 地址 |
Winona Lake IN US |
