Methods for Treating Pancreatic Cancer Using Combination Therapies Comprising Liposomal Irinotecan

摘要

Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.

主权项

1. A method of treating an exocrine pancreatic cancer, the method comprising intravenously administering to a human patient having an exocrine pancreatic cancer 60-80 mg/m2 of irinotecan in an irinotecan liposome injection formulation having a total volume of 500 mL over about 90 minutes, in combination with a therapeutically effective amount of leucovorin and 5-fluorouracil, to treat the exocrine pancreatic cancer in the patient, the irinotecan liposome injection formulation comprising an irinotecan liposome having irinotecan encapsulated within a liposome comprising phosphatidylcholine, cholesterol, and a polyethyleneglycol-derivatized phosphatidyl-ethanolamine, and the irinotecan liposome having a diameter of approximately 80-140 nm.