摘要 |
Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.; |
主权项 |
1. A compound as represented by formula I, and a pharmaceutically acceptable salt or prodrug thereof, wherein, R1 is selected from H, amino, hydroxy or sulfydryl, R2 is selected from H, amino, hydroxy, sulfydryl or —(CH2)nNHR8, wherein n=1-5, R8 is H or C1-3 alkyl; R3 is selected from H or C1-6 alkyl; R4, R5 and R6 are each independently selected from H, halogen, C1-6 alkyl or halogen substituted alkyl; and R7 is selected from H, C1-6 alkyl or halogen; or, R2 and R3 together with the carbon atom connecting them form substituted or unsubstituted 5- or 6-membered ring having 1 to 2 heteroatoms, wherein the heteroatoms are N, O or S, and the substituent is C1-6 alkyl. |