PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF FURAN-2,5-DICARBOXYLIC ACID OR DERIVATIVES THEREOF

摘要

Disclosed is a method of making 5-formyl-2-furoic acid and furan-2,5-dicarboxylic acid. The method involves the use of 5-keto-aldonic acids as intermediates, as these can be subjected to ring formation by a cyclodehydration reaction under mild conditions. The 5-formyl-2-furoic acid or carboxylic derivative thereof is subjected to oxidation so as to form furan-2,5-dicarboxylic acid. The 5-keto-aldonic acid intermediates can be obtained by isomerization of uronic acids which can be obtained from sugar beet pulp, chicory pulp, fruit peals including orange peels, or non-terrestrial sources like seaweeds. A preferred source is sugar beet pulp.

主权项

1. A process for the production of furan-2,5-dicarboxylic acid, or a carboxylic derivative thereof, comprising making 5-formyl-2-furoic acid, or a carboxylic derivative thereof, by a method comprising the steps of (i) providing an uronic acid; (ii) subjecting the uronic acid to isomerization so as to form the corresponding 5-keto-aldonic acid; (iii) subjecting said 5-keto-aldonic acid to cyclodehydration so as to produce 5-formyl-2-furoic acid or a carboxylic derivative thereof, and subjecting the 5-formyl-2-furoic acid, or the carboxylic derivative thereof, to oxidation so as to form furan-2,5-dicarboxylic acid, or a carboxylic derivative thereof.