| 摘要 |
The present invention provides a method for producing anterior eye segment tissue or a partial structure thereof, or a cellular aggregates containing precursor tissue thereof, by suspension culturing aggregates of pluripotent stem cells in the presence of a bone morphogenetic protein signaling pathway activator, inducing the self-organization of anterior eye segment tissue or a partial structure thereof, or precursor tissue thereof. In one embodiment, the bone morphogenetic protein signaling pathway activator is BMP4. In another embodiment, all or part of a suspension culture is produced in the presence of a fibroblast growth factor. The cellular aggregates that are produced may further contain neural retina tissue. |
