Polyamine Transporter Selective Compounds as Anti-Cancer Agents

摘要

Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.

主权项

1. An aromatic hydrocarbon tri-substituted with a polyamine, said tri-substituted aromatic hydrocarbon having the formula of compound 15: or a pharmaceutically acceptable salt thereof.