发明名称 |
METAL-ANTIBODY TAGGING AND PLASMA-BASED DETECTION |
摘要 |
An apparatus and method for characterizing a target, e.g., microbial samples or biological toxins, includes labeling the target with a biomolecular recognition construct and measuring an atomic-spectra signal of the biomolecular recognition construct. The method can include heating the labeled target before measuring the atomic-spectra signal. The atomic-spectra signal can be measured by performing laser-induced breakdown spectroscopy. The atomic-spectra signal can be measured by performing spark induced breakdown spectroscopy. The biomolecular recognition construct can be prepared by tagging a biological scaffolding with a metal atom or ion. In an aspect in which the target includes a microbial sample, the biological scaffolding can include an antibody against epitopes present on bacterial surface, the antibody linked to a heavy metal. In an aspect in which the target includes a biological toxin, the biological scaffolding can include an antibody against the biological toxin linked to heavy metals. |
申请公布号 |
WO2016040924(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
WO2015US49916 |
申请日期 |
2015.09.14 |
申请人 |
PURDUE RESEARCH FOUNDATION |
发明人 |
ROBINSON, JOSEPH, PAUL;RAJWA, BARTOLOMEJ, P.;PATSEKIN, VALERI, P.;BAE, EUIWON |
分类号 |
G01N33/53;C40B30/04;C40B60/10;G01N33/554;G01N33/567;G01N33/569 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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