TREATMENT OF TRAUMATIC BRAIN INJURY USING ANTIBODIES TO LYSOPHOSPHATIDIC ACID

摘要

Methods are provided for treating neurotrauma, for example, traumatic brain injury (TBI), using antibodies and antibody fragments that bind lysophosphatidic acid (LPA). Such treatment may result in functional locomotor recovery in subjects so treated, as well as reducing the size of a brain infarct in subjects having or suspected of having sustained neurotrauma such a TBI.

主权项

1. A method for treating neurotrauma, comprising administering to a subject having or suspected of having sustained neurotrauma a therapeutically effective amount of an antibody, or fragment thereof, that binds lysophosphatidic acid (LPA), thereby treating said neurotrauma, wherein the antibody or LPA-binding fragment thereof comprises:
a. at least one heavy chain variable domain comprising an amino acid sequence: EVQLVQSGAEVKKPGESLKISCQAFGDAFTNYLIEWVRQMPGQGLEWIGLIYPDSGYINYNENFKGQATLSADRSSS TAYLQWSSLKASDTAMYFCARRFAYYGSGYYFDYWGQGTMVTVSS (SEQ ID NO: 61); and b. at least one light chain variable domain comprising an amino acid sequence: DVVMTQTPLSLPVTPGEPASISCRSSQSLLKTNGNTYLHWYLQKPGQSPKLLIFKVSNRFSGVPDRFSGSGSGTDFT LKISRVEAEDVGVYFCSQSTHFPFTFGQGTKLEIK (SEQ ID NO: 42).