| 发明名称 |
MACROPINOCYTOSING HUMAN ANTI-CD46 ANTIBODIES AND TARGETED CANCER THERAPEUTICS |
| 摘要 |
In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors. |
| 申请公布号 |
CA2960282(A1) |
申请公布日期 |
2016.03.17 |
| 申请号 |
CA20152960282 |
申请日期 |
2015.09.10 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LIU, BIN;SU, YANG;BIDLINGMAIER, SCOTT;BEHRENS, CHRISTOPHER R.;LEE, NAMKYUNG |
| 分类号 |
C07K16/28;A61K31/40;A61K31/5517;A61K31/7036;A61K38/56;A61K39/395;A61P35/00;C07K16/30 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
