发明名称 |
PCV2 ORF2 protein variant and virus like particles composed thereof |
摘要 |
Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation. |
申请公布号 |
AU2014329524(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
AU20140329524 |
申请日期 |
2014.10.02 |
申请人 |
BOEHRINGER INGELHEIM VETMEDICA, INC. |
发明人 |
HERNANDEZ, LUIS ALEJANDRO;MUEHLENTHALER, CHRISTINE MARGARET;VAUGHN, ERIC MARTIN;HAIWICK, GREGORY |
分类号 |
C07K14/005;A61K39/12;C12N7/04 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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