| 发明名称 |
IMMUNOGENIC COMPOSITIONS CONTAINING ESCHERICHIA COLI H7 FLAGELLA AND METHODS OF USE THEREOF |
| 摘要 |
Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal. |
| 申请公布号 |
US2016074493(A1) |
申请公布日期 |
2016.03.17 |
| 申请号 |
US201514949291 |
申请日期 |
2015.11.23 |
| 申请人 |
The University Court of the University of Edinburgh ;Moredun Research Institute ;The Scottish Agricultural College |
发明人 |
GALLY David;MCNEILLY Tom Nathan;SMITH David George Emslie;LOW Chris;MAHAJAN Arvind Kumar;NAYLOR Stuart W. |
| 分类号 |
A61K39/108;C07K14/245;A61K39/39 |
主分类号 |
A61K39/108 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for generating a mucosal and/or IgA response in a subject in need thereof, said method comprising the parenteral administration of Escherichia coli H7 or a Toll-like receptor 5 (TLR5) activating fragment thereof. |
| 地址 |
Edinburgh GB |
