Aquaporin-4 Peptide Compositions and Methods of Use

摘要

The present disclosure provides human Aquaporin 4 (AQP4) peptides and peptides having homology to human Aquaporin 4 (AQP4) peptides. Also provided herein are methods for using human AQP4 peptides and peptides homologous to human AQP4 peptides for diagnosing and/or treating Neuromyelitis Optica.

主权项

1. A composition comprising:
a peptide comprising a contiguous stretch of amino acids having the consensus amino acid sequence:Leu-Pro-X1-X2-Met-X3-X4-Ile-X5-X6 wherein the peptide is up to 50 amino acids in length, and wherein X1 is Val (V) or Ile (I), X2 is Ser (S) or Asp (D), X3 is Val (V), Ile (I), or Gly (G), X4 is Leu (L) or Ile (I), X5 is Met (M) or Ser (S), and X6 is Leu (L), Val (V), or Ala (A).