发明名称 |
IDENTIFICATION OF IMMUNOLOGICALLY PROTECTIVE NEO-EPITOPES FOR THE TREATMENT OF CANCERS |
摘要 |
Described herein are methods of identifying immunologically protective neo-epitopes from the cancer tissue DNA of cancer patients using biophysical principles as well as bioinformatics techniques. The identification of immunologically protective neo-epitopes provides pharmaceutical compositions with a limited number of tumor-specific peptides suitable for personalized genomics-driven immunotherapy of human cancer. Specifically disclosed herein is a method of using the conformational stability of an epitope in an MHC protein -binding groove to predict immunogenicity of peptides in a putative neo-peptide set from a tumor from a cancer patient. Pharmaceutical compositions and methods of administration are also included. |
申请公布号 |
WO2016040110(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
WO2015US48345 |
申请日期 |
2015.09.03 |
申请人 |
THE UNIVERSITY OF CONNECTICUT;UNIVERSITY OF NOTRE DAME DUE LAC |
发明人 |
SRIVASTAVA, PRAMOD K.;BAKER, BRIAN M. |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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