DIBENZOATE ESTERS AND THE THERAPEUTIC USE THEREOF AS NEGATIVE MODULATORS OF POTASSIUM CHANNELS KCA2/3

摘要

The invention relates to a group of compounds, having a benzoate ester core, which can modulate the potassium channels of the KCa2/3 family, and are therefore suitable for the treatment of diseases or disorders in which these channels are implicated, such as hyperaemia, hypotension, tachycardia, heart failure, muscle weakness, hyperplasia, fibrosis, neuronal hypoexcitability, neurodegenerative diseases, pain, angiogenesis and tumour proliferation, chronic intestinal inflammation, epithelial and endothelial disorders, edema, secretory and cutaneous disorders, auto-immune, peripheral or neurological diseases, relating to abnormal activity of macrophages and T and B cells.