发明名称 |
PROCESS FOR PREPARING MICROPARTICLES |
摘要 |
A process for preparing microparticles comprising a biologically active material and a polymer and having a mean particle size expressed as the volume mean diameter (VMD) of from 10 to 500 μm, wherein the biologically active material is substantially insoluble in the polymer, which process comprises: a. contacting a mixture of the biologically active material or a precursor thereof, the polymer or a precursor thereof and a processing aid with a supercritical fluid which is capable of swelling the polymer under temperature and pressure conditions necessary to maintain the fluid in a supercritical state; b. allowing the supercritical fluid to penetrate and liquefy the polymer, whilst maintaining the temperature and pressure conditions so that the fluid is maintained in a supercritical state; c. releasing the pressure to precipitate microparticles comprising the biologically active agent and the polymer. |
申请公布号 |
US2016074327(A1) |
申请公布日期 |
2016.03.17 |
申请号 |
US201514947695 |
申请日期 |
2015.11.20 |
申请人 |
Critical Pharmaceuticals Limited |
发明人 |
Naylor Andrew;Lewis Andrew Lester;Illum Lisbeth |
分类号 |
A61K9/16;A61K31/519;A61K9/14;A61K38/38 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
1. A process for preparing microparticles comprising a biologically active material and a polymer, said microparticles having a mean particle size expressed as the volume mean diameter (VMD) of from 10 to 500 μm, wherein the biologically active material is substantially insoluble in the polymer, which process comprises:
a. contacting a mixture of the biologically active material or a precursor thereof, the polymer or a precursor thereof and a processing aid with a supercritical fluid which is capable of swelling the polymer under temperature and pressure conditions necessary to maintain the fluid in a supercritical state; b. allowing the supercritical fluid to penetrate and liquefy the polymer, whilst maintaining the temperature and pressure conditions so that the fluid is maintained in a supercritical state; and c. releasing the pressure to precipitate microparticles comprising the biologically active agent and the polymer. |
地址 |
Nottingham GB |