The invention relates to the development of chimeric OspA molecules for use in against Lyme disease or borreliosis vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies.
申请公布号
AU2011252850(B2)
申请公布日期
2016.03.17
申请号
AU20110252850
申请日期
2011.05.13
申请人
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;BAXTER HEALTHCARE S.A.;BAXTER INTERNATIONAL INC.;BROOKHAVEN SCIENCE ASSOCIATES, LLC
发明人
CROWE, BRIAN A.;LIVEY, IAN;O'ROURKE, MARIA;SCHWENDINGER, MICHAEL;DUNN, JOHN J.;LUFT, BENJAMIN J.