COMPOSITIONS AND METHODS FOR REGULATING THERMOGENESIS AND MUSCLE INFLAMMATION USING METRNL AND METRN
摘要
The invention provides compositions and methods for regulating thermogenesis and muscle inflammation through modulation of Metrnl and/or Metrn activity and/or expression. Also provided are methods for preventing or treating metabolic disorders and muscle inflammation disorders in a subject through modulation of Metrnl and/or Metrn activity and/or expression. Further provided are methods for identifying compounds that are capable of treating metabolic disorders and muscle inflammation disorders by modulating Metrnl and/or Metrn activity and/or expression.
申请公布号
WO2014116556(A3)
申请公布日期
2016.03.17
申请号
WO2014US12243
申请日期
2014.01.21
申请人
DANA-FARBER CANCER INSTITUTE, INC.
发明人
SPIEGELMAN, BRUCE, M.;RAO, RAJESH, R.;LONG, JONATHAN, Z.