发明名称 |
STRUCTURAL-BASED INHIBITORS OF THE GLUTATHIONE BINDING SITE IN ALDOSE REDUCTASE, METHODS OF SCREENING THEREFOR AND METHODS OF USE |
摘要 |
Provided herein are methods of treating a pathophysiological state or symptoms thereof resulting from aldose reductase-mediated signaling in a cytotoxic pathway in a subject using an inhibitor of aldose reductase. Particularly, specific inhibitors may be a small- interfering RNA (siRNA) or may be inhibitors of glutathi one-aldehyde binding to aldose reductase which are designed via at least computer modeling of the ternary A R: NA DPH: DCEG structure. Also, methods of treating a cancer or suppressing metastasis thereof using the siRNAs and aldose reductase inhibitors are provided. |
申请公布号 |
EP2032145(B1) |
申请公布日期 |
2016.03.16 |
申请号 |
EP20070810130 |
申请日期 |
2007.06.29 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SRIVASTAVA, SATISH, K.;RAMANA, KOTA, V. |
分类号 |
A61K31/70 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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