The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions are also provided.
申请公布号
EP2235008(B1)
申请公布日期
2016.03.16
申请号
EP20080855867
申请日期
2008.12.05
申请人
JANSSEN SCIENCES IRELAND UC
发明人
JONCKERS, TIM HUGO MARIA;SCHEPENS, WIM BERT GRIET;HACHÉ, GEERWIN YVONNE PAUL;HALLENBERGER, BEATE SABINE;SASAKI, JENNIFER CHIYOMI;BAUMEISTER, JUDITH EVA;VAN 'T KLOOSTER, GERBEN ALBERT ELEUTHERIUS
