发明名称 |
Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles |
摘要 |
The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of “zinc-containing metal oxide nanoparticle—biologically/chemically active material” in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials. |
申请公布号 |
EP2131870(B1) |
申请公布日期 |
2016.03.16 |
申请号 |
EP20080741295 |
申请日期 |
2008.04.11 |
申请人 |
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY |
发明人 |
CHEON, JIN-WOO;JUN, YOUNG-WOOK;JANG, JUNG-TAK |
分类号 |
A61K49/06;A61K49/18;B22F1/00 |
主分类号 |
A61K49/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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