| 发明名称 |
Spirocyclic compounds as tryptophan hydroxylase inhibitors |
| 摘要 |
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer. |
| 申请公布号 |
AU2014315109(A1) |
申请公布日期 |
2016.03.17 |
| 申请号 |
AU20140315109 |
申请日期 |
2014.09.05 |
| 申请人 |
KAROS PHARMACEUTICALS, INC. |
发明人 |
DE LOMBAERT, STEPHANE;GOLDBERG, DANIEL R.;BRAMELD, KENNETH;SJOGREN, ERIC BRIAN;SCRIBNER, ANDREW |
| 分类号 |
C07D471/10;A61K31/438;A61P1/00;A61P9/00;A61P29/00;A61P35/00 |
主分类号 |
C07D471/10 |
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