发明名称 |
PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS |
摘要 |
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. R1, R2, R3, R4, Q have meanings given in the description. |
申请公布号 |
EP2791130(B1) |
申请公布日期 |
2016.03.16 |
申请号 |
EP20120812914 |
申请日期 |
2012.12.14 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
HEIMANN, ANNEKATRIN;DAHMANN, GEORG;GRUNDL, MARC;MUELLER, STEPHAN GEORG;WELLENZOHN, BERND |
分类号 |
C07D401/14;A61K31/497;A61P25/16;A61P25/18;C07D403/06;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D471/04;C07D513/04 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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