对醋酸格拉替雷（ＧＬＡＴＩＲＡＭＥＲ ＡＣＥＴＡＴＥ）之反应具预测性之基因标记

摘要

明提供一种用包含醋酸格拉替雷(Glatiramer Acetate)及医药学上可接受之载剂之医药组合物治疗罹患多发性硬化症或与多发性硬化症一致的单次临床发作之人类个体的方法，其包含以下步骤：(i)在对应于一或多个选自由组1组成之群的单核苷酸多形现象(SNP)之位置的位置处判定该个体之基因型：(ii)若该个体之该基因型含有以下各者，则将该个体识别为对醋酸格拉替雷(Glatiramer Acetate)之预测反应者：一或多个在组2位置处之A对偶基因，一或多个在组3位置处之C对偶基因，一或多个在组4位置处之G对偶基因，或一或多个在kgp18432055、kgp279772、kgp3991733或kgp7242489位置处之T对偶基因；及(iii)仅当该个体被识别为对醋酸格拉替雷之预测反应者时才向该个体投与包含醋酸格拉替雷及医药学上可接受之载剂的该医药组合物。

主权项

一种用包含醋酸格拉替雷(Glatiramer Acetate)及医药学上可接受之载剂之医药组合物治疗罹患多发性硬化症或与多发性硬化症一致的单次临床发作之人类个体的方法，其包含以下步骤：(i)在对应于一或多个选自由以下各者组成之群的单核苷酸多形现象(SNP)之位置的位置处判定该个体之基因型：kgp10090631、kgp1009249、kgp10152733、kgp10224254、kgp10305127、kgp10351364、kgp10372946、kgp10404633、kgp10412303、kgp10523170、kgp1054273、kgp10558725、kgp10564659、kgp10591989、kgp10594414、kgp10619195、kgp10620244、kgp10632945、kgp10633631、kgp10679353、kgp10788130、kgp10826273、kgp10910719、kgp10922969、kgp10948564、kgp10967046、kgp10974833、kgp1098237、kgp11002881、kgp11010680、kgp11077373、kgp11141512、kgp11206453、kgp11210903、kgp1124492、kgp11281589、kgp11285862、kgp11328629、kgp11356379、kgp11407560、kgp11453406、kgp11467007、kgp11514107、kgp11543962、kgp11580695、kgp11627530、kgp11633966、kgp11686146、kgp11702474、kgp11711524、kgp11768533、kgp11804835、kgp11843177、kgp12008955、kgp12083934、kgp12182745、kgp12230354、kgp1224440、kgp12371757、kgp124162、kgp12426624、kgp12557319、kgp1285441、kgp13161760、kgp1355977、kgp1371881、kgp15390522、kgp1683448、kgp1688752、kgp1699628、kgp1753445、kgp1779254、kgp1786079、kgp18379774、kgp18432055、kgp18525257、
kgp1912531、kgp19568724、kgp20163979、kgp2023214、kgp2045074、kgp20478926、kgp2092817、kgp21171930、kgp2245775、kgp2262166、kgp22778566、kgp22793211、kgp22811918、kgp22823022、kgp2282938、kgp2299675、kgp23298674、kgp2356388、kgp23672937、kgp23737989、kgp2388352、kgp2391411、kgp24131116、kgp24415534、kgp2446153、kgp2451249、kgp2465184、kgp24729706、kgp24753470、kgp25191871、kgp25216186、kgp25543811、kgp25921291、kgp25952891、kgp26026546、kgp26271158、kgp2638591、kgp26528455、kgp26533576、kgp2688306、kgp26995430、kgp270001、kgp2709692、kgp2715873、kgp27500525、kgp27571222、kgp27640141、kgp2788291、kgp279772、kgp28532436、kgp28586329、kgp28687699、kgp28817122、kgp2923815、kgp29367521、kgp293787、kgp2958113、kgp2959751、kgp297178、kgp29794723、kgp30282494、kgp3048169、kgp304921、kgp3182607、kgp3202939、kgp3205849、kgp3218351、kgp3267884、kgp3276689、kgp337461、kgp3418770、kgp3450875、kgp345301、kgp3477351、kgp3496814、kgp355027、kgp355723、kgp3593828、kgp3598409、kgp3651767、kgp3669685、kgp3730395、kgp3812034、kgp3854180、kgp3933330、kgp3951463、kgp3984567、kgp3991733、kgp4011779、kgp4056892、kgp4096263、kgp4127859、kgp4155998、kgp4162414、kgp4223880、kgp4346717、kgp4370912、kgp4418535、kgp4420791、kgp4479467、kgp4524468、kgp4543470、kgp4559907、kgp4573213、
kgp4634875、kgp4705854、kgp4734301、kgp4755147、kgp4812831、kgp4842590、kgp485316、kgp487328、kgp4898179、kgp5002011、kgp5014707、kgp5017029、kgp5053636、kgp5068397、kgp512180、kgp5144181、kgp5159037、kgp5216209、kgp5292386、kgp5334779、kgp5388938、kgp5409955、kgp5440506、kgp5441587、kgp5483926、kgp55646、kgp5564995、kgp5579170、kgp5680955、kgp5869992、kgp5908616、kgp6023196、kgp6032617、kgp6038357、kgp6076976、kgp6091119、kgp6127371、kgp61811、kgp6190988、kgp6214351、kgp6228750、kgp6236949、kgp6469620、kgp6505544、kgp6507761、kgp652534、kgp6539666、kgp6567154、kgp6599438、kgp6603796、kgp6666134、kgp6700691、kgp6737096、kgp6768546、kgp6772915、kgp6835138、kgp6959492、kgp6996560、kgp7059449、kgp7063887、kgp7077322、kgp7092772、kgp7117398、kgp7121374、kgp7178233、kgp7181058、kgp7186699、kgp7189498、kgp7242489、kgp7331172、kgp7416024、kgp7481870、kgp7506434、kgp7521990、kgp759150、kgp767200、kgp7714238、kgp7730397、kgp7747883、kgp7792268、kgp7802182、kgp7804623、kgp7924485、kgp8030775、kgp8036704、kgp8046214、kgp8106690、kgp8107491、kgp8110667、kgp8169636、kgp8174785、kgp8178358、kgp8183049、kgp8192546、kgp8200264、kgp8303520、kgp8335515、kgp8372910、kgp841428、kgp8437961、kgp8440036、kgp85534、kgp8599417、kgp8602316、
kgp8615910、kgp8767692、kgp8777935、kgp8793915、kgp8796185、kgp8817856、kgp8869954、kgp8990121、kgp9018750、kgp9071686、kgp9078300、kgp9320791、kgp9354462、kgp9354820、kgp9368119、kgp9410843、kgp9421884、kgp9450430、kgp9530088、kgp9551947、kgp9601362、kgp9627338、kgp9627406、kgp9669946、kgp9699754、kgp971582、kgp97310、kgp974569、kgp9795732、kgp9806386、kgp9854133、kgp9884626、rs10049206、rs10124492、rs10125298、rs10162089、rs10201643、rs10203396、rs10251797、rs10278591、rs10489312、rs10492882、rs10498793、rs10501082、rs10510774、rs10512340、rs1079303、rs10815160、rs10816302、rs10841322、rs10841337、rs10954782、rs11002051、rs11022778、rs11029892、rs11029907、rs11029928、rs11083404、rs11085044、rs11136970、rs11147439、rs11192461、rs11192469、rs11559024、rs1157449、rs11648129、rs11691553、rs12013377、rs12494712、rs12943140、rs13002663、rs13394010、rs13415334、rs13419758、rs1380706、rs1387768、rs1410779、rs1478682、rs1508102、rs1532365、rs1544352、rs1545223、rs1579771、rs1604169、rs1621509、rs1644418、rs16886004、rs16895510、rs16901784、rs16927077、rs16930057、rs17029538、rs17224858、rs17238927、rs17329014、rs17400875、rs17449018、rs17577980、rs17638791、rs1858973、rs1886214、rs1894406、rs1894407、rs1894408、rs196295、rs196341、rs196343、rs197523、rs1979992、rs1979993、rs2043136、
rs2058742、rs2071469、rs2071470、rs2071472、rs2074037、rs2136408、rs2139612、rs2175121、rs2241883、rs2309760、rs2325911、rs241435、rs241440、rs241442、rs241443、rs241444、rs241445、rs241446、rs241447、rs241449、rs241451、rs241452、rs241453、rs241454、rs241456、rs2453478、rs2598360、rs2621321、rs2621323、rs2660214、rs2816838、rs2824070、rs2839117、rs2845371、rs2857101、rs2857103、rs2857104、rs2926455、rs2934491、rs3135388、rs3218328、rs343087、rs343092、rs3767955、rs3792135、rs3799383、rs3803277、rs3815822、rs3818675、rs3829539、rs3885907、rs3899755、rs4075692、rs4143493、rs419132、rs423239、rs4254166、rs4356336、rs4360791、rs4449139、rs4584668、rs4669694、rs4709792、rs4738738、rs4769060、rs4780822、rs4782279、rs4822644、rs484482、rs4894701、rs5024722、rs502530、rs543122、rs6032205、rs6032209、rs6110157、rs623011、rs6497396、rs6535882、rs6687976、rs6718758、rs6835202、rs6840089、rs6845927、rs6895094、rs6899068、rs7020402、rs7024953、rs7028906、rs7029123、rs7062312、rs714342、rs7187976、rs7191155、rs720176、rs7217872、rs7228827、rs7348267、rs7496451、rs7524868、rs7563131、rs7579987、rs759458、rs7666442、rs7670525、rs7672014、rs7677801、rs7725112、rs7844274、rs7850、rs7860748、rs7862565、rs7864679、rs7928078、rs7948420、rs8035826、rs8050872、rs8053136、rs8055485、rs823829、rs858341、rs9315047、rs931570、rs9346979、rs9376361、rs9393727、rs9501224、rs9508832、rs950928、rs9579566、
rs9597498、rs9670531、rs9671124、rs9671182、rs9817308、rs9834010、rs9876830、rs9913349、rs9931167及rs9931211，(ii)若该个体之该基因型含有以下各者，则将该个体识别为对醋酸格拉替雷之预测反应者：一或多个在以下位置处之A对偶基因：kgp10152733、kgp10224254、kgp10305127、kgp10351364、kgp10372946、kgp10404633、kgp10564659、kgp10591989、kgp10594414、kgp10619195、kgp10620244、kgp10633631、kgp10974833、kgp11002881、kgp11285862、kgp11328629、kgp11407560、kgp11514107、kgp11627530、kgp11702474、kgp11711524、kgp11768533、kgp11804835、kgp12083934、kgp12182745、kgp12230354、kgp1224440、kgp124162、kgp12557319、kgp1371881、kgp1699628、kgp1753445、kgp1779254、kgp1786079、kgp18379774、kgp18525257、kgp20163979、kgp2023214、kgp20478926、kgp21171930、kgp2262166、kgp22778566、kgp2465184、kgp24753470、kgp25191871、kgp25216186、kgp25952891、kgp26026546、kgp26533576、kgp27500525、kgp27571222、kgp28532436、kgp28586329、kgp28817122、kgp2958113、kgp29794723、kgp30282494、kgp304921、kgp3205849、kgp3218351、kgp3276689、kgp337461、kgp345301、kgp355027、kgp355723、kgp3593828、kgp3812034、kgp3951463、kgp4162414、kgp4223880、kgp4418535、kgp4543470、kgp4573213、kgp4634875、kgp4755147、kgp4842590、kgp485316、kgp5068397、kgp5334779、kgp5483926、kgp5564995、kgp5869992、kgp5908616、kgp6032617、kgp6038357、
kgp6076976、kgp6091119、kgp6127371、kgp61811、kgp6214351、kgp6228750、kgp6236949、kgp6469620、kgp6505544、kgp6507761、kgp6666134、kgp6700691、kgp6772915、kgp6959492、kgp7077322、kgp7117398、kgp7178233、kgp7186699、kgp7506434、kgp759150、kgp7730397、kgp7802182、kgp7804623、kgp7924485、kgp8030775、kgp8036704、kgp8046214、kgp8106690、kgp8110667、kgp8178358、kgp8200264、kgp8372910、kgp841428、kgp8602316、kgp8615910、kgp8793915、kgp8796185、kgp8990121、kgp9018750、kgp9354462、kgp9368119、kgp9410843、kgp9450430、kgp9530088、kgp9627338、kgp9669946、kgp97310、kgp974569、kgp9806386、kgp9884626、rs10049206、rs10124492、rs10125298、rs10162089、rs10203396、rs10251797、rs10278591、rs10489312、rs10492882、rs10498793、rs10501082、rs10510774、rs10512340、rs10815160、rs10816302、rs10841337、rs11029892、rs11029928、rs11192469、rs11559024、rs11648129、rs12013377、rs13394010、rs13415334、rs1478682、rs1544352、rs1545223、rs1604169、rs1621509、rs1644418、rs17029538、rs17400875、rs17449018、rs17577980、rs1858973、rs1894406、rs1894407、rs197523、rs2058742、rs2071469、rs2071472、rs2139612、rs2241883、rs2309760、rs241440、rs241442、rs241444、rs241445、rs241446、rs241449、rs241453、rs241456、rs2453478、rs2660214、rs2824070、rs2845371、rs2857103、rs2926455、rs343087、rs343092、
rs3767955、rs3792135、rs3829539、rs3899755、rs4075692、rs4143493、rs423239、rs4254166、rs4356336、rs4584668、rs4780822、rs4782279、rs5024722、rs6032209、rs6110157、rs623011、rs6497396、rs6845927、rs6895094、rs6899068、rs7024953、rs7028906、rs7029123、rs7062312、rs7187976、rs7191155、rs720176、rs7228827、rs7496451、rs7563131、rs759458、rs7666442、rs7670525、rs7677801、rs7725112、rs7850、rs7862565、rs7948420、rs8035826、rs8053136、rs8055485、rs823829、rs9315047、rs9501224、rs9508832、rs950928、rs9597498、rs9670531、rs9671124、rs9817308、rs9834010、rs9876830或rs9931211，一或多个在以下位置处之C对偶基因：kgp10910719、kgp11077373、kgp11453406、kgp12426624、kgp2045074、kgp22811918、kgp23298674、kgp2709692、kgp28687699、kgp3496814、kgp3669685、kgp3730395、kgp4056892、kgp4370912、kgp5053636、kgp5216209、kgp5292386、kgp6023196、kgp652534、kgp7059449、kgp7189498、kgp7521990、kgp7792268、kgp8303520、kgp9320791、kgp9795732、rs10201643、rs11022778、rs11136970、rs11147439、rs11691553、rs1579771、rs16901784、rs2136408、rs2325911、rs241443、rs2857104、rs3803277、rs3885907、rs4738738、rs4894701、rs502530、rs6032205、rs6687976、rs6718758、rs6835202、rs714342、rs7524868、rs7844274、rs9393727或rs9671182，一或多个在以下位置处之G对偶基因：kgp10090631、kgp1009249、kgp10412303、kgp10523170、kgp1054273、
kgp10558725、kgp10632945、kgp10679353、kgp10788130、kgp10826273、kgp10922969、kgp10948564、kgp10967046、kgp1098237、kgp11010680、kgp11141512、kgp11206453、kgp11210903、kgp1124492、kgp11281589、kgp11356379、kgp11467007、kgp11543962、kgp11580695、kgp11633966、kgp11686146、kgp11843177、kgp12008955、kgp12371757、kgp1285441、kgp13161760、kgp1355977、kgp15390522、kgp1683448、kgp1688752、kgp1912531、kgp19568724、kgp2092817、kgp2245775、kgp22793211、kgp22823022、kgp2282938、kgp2299675、kgp2356388、kgp23672937、kgp23737989、kgp2388352、kgp2391411、kgp24131116、kgp24415534、kgp2446153、kgp2451249、kgp24729706、kgp25543811、kgp25921291、kgp26271158、kgp2638591、kgp26528455、kgp2688306、kgp26995430、kgp270001、kgp2715873、kgp27640141、kgp2788291、kgp2923815、kgp29367521、kgp293787、kgp2959751、kgp297178、kgp3048169、kgp3182607、kgp3202939、kgp3267884、kgp3418770、kgp3450875、kgp3477351、kgp3598409、kgp3651767、kgp3854180、kgp3933330、kgp3984567、kgp4011779、kgp4096263、kgp4127859、kgp4155998、kgp4346717、kgp4420791、kgp4479467、kgp4524468、kgp4559907、kgp4705854、kgp4734301、kgp4812831、kgp487328、kgp4898179、kgp5002011、kgp5014707、kgp5017029、kgp512180、kgp5144181、kgp5159037、kgp5388938、kgp5409955、kgp5440506、kgp5441587、kgp55646、kgp5579170、kgp5680955、kgp6190988、
kgp6539666、kgp6567154、kgp6599438、kgp6603796、kgp6737096、kgp6768546、kgp6835138、kgp6996560、kgp7063887、kgp7092772、kgp7121374、kgp7181058、kgp7331172、kgp7416024、kgp7481870、kgp767200、kgp7714238、kgp7747883、kgp8107491、kgp8169636、kgp8174785、kgp8183049、kgp8192546、kgp8335515、kgp8437961、kgp8440036、kgp85534、kgp8599417、kgp8767692、kgp8777935、kgp8817856、kgp8869954、kgp9071686、kgp9078300、kgp9354820、kgp9421884、kgp9551947、kgp9601362、kgp9627406、kgp9699754、kgp971582、kgp9854133、rs1079303、rs10841322、rs10954782、rs11002051、rs11029907、rs11083404、rs11085044、rs11192461、rs1157449、rs12494712、rs12943140、rs13002663、rs13419758、rs1380706、rs1387768、rs1410779、rs1508102、rs1532365、rs16886004、rs16895510、rs16927077、rs16930057、rs17224858、rs17238927、rs17329014、rs17638791、rs1886214、rs1894408、rs196295、rs196341、rs196343、rs1979992、rs1979993、rs2043136、rs2071470、rs2074037、rs2175121、rs241435、rs241447、rs241451、rs241452、rs241454、rs2598360、rs2621321、rs2621323、rs2816838、rs2839117、rs2857101、rs2934491、rs3135388、rs3218328、rs3799383、rs3815822、rs3818675、rs419132、rs4360791、rs4449139、rs4669694、rs4709792、rs4769060、rs4822644、rs484482、rs543122、rs6535882、rs6840089、rs7020402、rs7217872、rs7348267、rs7579987、rs7672014、rs7860748、rs7864679、
rs7928078、rs8050872、rs858341、rs931570、rs9346979、rs9376361、rs9579566、rs9913349或rs9931167，或一或多个在kgp18432055、kgp279772、kgp3991733或kgp7242489位置处之T对偶基因；及(iii)仅当该个体被识别为对醋酸格拉替雷之预测反应者时才向该个体投与包含醋酸格拉替雷及医药学上可接受之载剂的该医药组合物。