发明名称 |
FUNCTIONAL POLYMER FILM-COATED PARTICLE HAVING HIGH DRUG CONTENT, TABLET CONTAINING SAME, AND METHODS FOR PRODUCTION THEREOF |
摘要 |
Provided are functional drug-containing particles which can be compressed into tablets and in particular, to orally disintegrating tablets by employing any of a dry molding method, a wet molding method, or a humidifying drying method. The functional drug-containing particles comprise substantially spherical drug-containing particles essentially including drug and a binder, the functional drug-containing particles including a functional polymer film selected from the group consisting of an enteric film, a release control film, and a bitter taste masking film, an average particle diameter of said functional drug-containing particles being 400 µm or less, a particle diameter ratio D 90 /D 10 of the functional drug-containing particles with respect to particle size distribution calculated on a volumetric basis being 1.65 or more, or a coefficient of variation in particle diameters being 24% or more. |
申请公布号 |
EP2995299(A1) |
申请公布日期 |
2016.03.16 |
申请号 |
EP20130884151 |
申请日期 |
2013.05.08 |
申请人 |
ZENSEI PHARMACEUTICAL INDUSTRIES CO., LTD.;POWREX CORPORATION |
发明人 |
HAYASHIDA, TOMOHIRO;YAMAZAKI, JUNJI;NAKANO, YOSHIO;HIZAKI, MASAYA;KINOSHITA, NAOTOSHI |
分类号 |
A61K9/20;A61K9/16;A61K9/50;A61K31/137;A61K31/522 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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