发明名称 |
Soluble CTLA4 mutant molecules and uses thereof |
摘要 |
The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule. |
申请公布号 |
EP1536234(B1) |
申请公布日期 |
2016.03.16 |
申请号 |
EP20040008908 |
申请日期 |
2001.05.23 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
PEACH, ROBERT J.;NAEMURA, JOSEPH R.;LINSLEY, PETER S.;BAJORATH, JÜRGEN |
分类号 |
C07K14/705;C12N15/09;A61K38/00;A61K45/00;A61P37/00;A61P37/06;C07K;C07K14/47;C07K16/00;C07K19/00;C12N5/10;C12P21/02;C12Q1/02;G01N33/68 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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