| 摘要 |
The invention concerns pharmaceutical compositions containing two active principles, one of which is a known non-steroidal anti-inflammatory analgesic, such as meloxicam or one of the pharmaceutically acceptable salts thereof, and the other is a known non-steroidal anti-inflammatory analgesic, such as lysine clonixinate. When the two drugs are combined in specific proportions, the combination produces analgesic pharmacological effects which indicate superadditivity (synergy) and potentiation of the anti-inflammatory effect, such that smaller amounts of the two drugs can be used in order to attain the same therapeutic effects than when they are used alone. Owing to the reduction in the amount of each drug in the combination, the collateral effects associated with each drug are fewer and less pronounced, such that this therapeutic strategy can be a promising tool in the relief of moderate to severe acute pain with the advantage of having fewer adverse effects. |
