Methods and products for diagnosing autoimmune disease and gastric cancer linked with atrophic gastritis

摘要

The present invention relates to a method for examining a person having symptoms and/or biomarkers indicating an autoimmune disease for the presence of atrophic gastritis. The biomarker combination, which diagnoses atrophic gastritis, acts also as a part of a biomarker panel that helps diagnosis and assessment of autoimmune disease as well. The invention relates also to products used in these methods.

主权项

1. A method for determining the presence of Helicobacter pylori infection and/or atrophic gastritis in a person diagnosed as having symptoms of diabetes mellitus type 1, said method comprising the steps of:
a) obtaining a biological sample from the person diagnosed as having symptoms of diabetes mellitus type 1; b) quantitatively measuring a plurality of biomarkers from said biological sample with a non-invasive test(s), wherein said plurality of biomarkers comprises pepsinogen I, pepsinogen II, pepsinogen I/II ratio, gastrin-17 and Helicobacter pylori antibodies, and wherein the pepsinogen I, pepsinogen II and gastrin-17 are measured using an antibody; c) comparing the values obtained to cut-off values or reference ranges; and d) determining that said person diagnosed as having symptoms of diabetes mellitus type 1 has a Helicobacter pylori infection and/or atrophic gastritis, based on said comparing.