Human anti-SOD1 antibodies

摘要

Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for SOD1 targeted immunotherapy and diagnosis, respectively.

主权项

1. A cDNA molecule encoding a human anti-SOD1 antibody or an antigen-binding fragment thereof capable of binding to misfolded or aggregated SOD1; wherein the encoded antibody or antigen-binding fragment thereof comprises in its variable region the complementarity determining regions (CDRs) depicted in any one of FIGS. 1A-1L, and wherein the encoded antibody
(i) binds to physiological SOD1 dimers (ii) preferentially recognizes the misfolded or aggregated SOD1 over physiological SOD1 dimers, or (iii) does not substantially recognize physiological SOD1 dimers.